SerialMagic is supported on a variety of desktop and mobile operating systems, as shown in the list below.
- Android (with SerialMagic Gears on Android 2.1 and later)
- Windows 2000, XP, 2003, Vista, 7, 8, and 10 (SerialMagic Professional)
- Windows Mobile 6 Professional & Classic, Windows Mobile 5 Pocket-PC (touchscreen devices)
- Apple Mac OS X (with SerialMagic Professional on OS X 10.6 and later)